Enhancing Irreversible Electroporation by Manipulating Cellular Biophysics with a Molecular Adjuvant
نویسندگان
چکیده
منابع مشابه
Tumor Ablation with Irreversible Electroporation
We report the first successful use of irreversible electroporation for the minimally invasive treatment of aggressive cutaneous tumors implanted in mice. Irreversible electroporation is a newly developed non-thermal tissue ablation technique in which certain short duration electrical fields are used to permanently permeabilize the cell membrane, presumably through the formation of nanoscale def...
متن کاملTemperature considerations during irreversible electroporation
a School of Biomedical Engineering and Sciences, Virginia Tech-Wake Forest University, Blacksburg, VA 24061, USA Department of Bioengineering, Department of Mechanical Engineering and Graduate Program in Biophysics, University of California at Berkeley, Berkeley, CA 94720, USA Center for Bioengineering in the Service of Humanity and Society, School of Computer Science and Engineering, Hebrew Un...
متن کاملA Multi Objective Genetic Algorithm (MOGA) for Optimizing Thermal and Electrical Distribution in Tumor Ablation by Irreversible Electroporation
Background: Irreversible electroporation (IRE) is a novel tumor ablation technique. IRE is associated with high electrical fields and is often reported in conjunction with thermal damage caused by Joule heating. For good response to surgery it is crucial to produce minimum thermal damage in both tumoral and healthy tissues named Non-Thermal Irreversible Electroporation(NTIRE). Non-thermal irrev...
متن کاملTissue heating during tumor ablation with irreversible electroporation
Exposing biological cells to sufficiently strong external electric fields causes electroporation of cell membranes, i.e. occurrence of transient or permanent permeable pathways between the interior and exterior of the cell. Electroporation can be used to introduce various molecules into cells (reversible electroporation) or to kill cells (irreversible electroporation), which can in turn be used...
متن کاملAblation of perivascular hepatic malignant tumors with irreversible electroporation.
BACKGROUND Ablation is increasingly used to treat primary and secondary liver cancer. Ablation near portal pedicles and hepatic veins is challenging. Irreversible electroporation (IRE) is a new ablation technique that does not rely on heat and, in animals, appears to be safe and effective when applied near hepatic veins and portal pedicles. This study evaluated the safety and short-term outcome...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2017
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2017.06.014